Pipeline

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Immunotherapy

Immunotherapy is one of the most important advances of modern times within oncology. Unfortunately, many immunotherapies-  are toxic when given systemically. Despite a track-record of success in animal models, including dramatic tumor regressions, many of these therapies have not been moved into broad human clinical trials because of serious, dose-limiting toxicities. 

While progress has been made with immune checkpoint inhibitors, which release the "brakes" of the immune system, similar progress to stimulate the immune system directly has been lacking. We deliver a therapy (NR-01) that activates the immune system in a precise manner.  Nano RED has developed preclinical proof-of-concept demonstrating that this platform works in animal models. 

Partnered Products

One of the major advantages of this platform is the ability to package many different agents, ranging from small molecules to proteins for clinician-triggered, tumor-specific release. This has enabled us to collaborate with other entities to customize the delivery platform to meet the unique needs of their therapeutics.

The broad spectrum of potential molecules that Nano RED's platform can deliver, along with our commitment to partnership are key elements of our strategy to roll the platform out for use in the treatment of many different cancers.

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Target Indications

NanoRED's mission is to change the way that cancer is treated. To do this, we will pursue a rapid clinical trial strategy. Our initial target indications include triple negative breast cancer (TNBC), and soft tissue sarcomas, where our focus will initially be on orphan indications such as rhabdomyosarcoma, allowing for faster and more efficient clinical trials. Soft tissue sarcomas are highly vascular, and situated ideally for treatment with IR-activated therapies. In addition, the dramatic clinical need, coupled with Orphan Disease status enhances our ability to partner with other pharmaceutical entities to facilitate rapid development of NR-01. Preclinical work has also validated this platform in mouse models of breast cancer.